Antioxidant Mechanisms Underlying the Gastroprotective Effect of Menthofuran on Experimentally Induced Gastric Lesions in Rodents

Author:

Alves Naira Moura1,Nunes Paulo Humberto Moreira12,Mendes Garcez Anderson2ORCID,Lima de Freitas Manoela Carine2ORCID,Oliveira Irisdalva Sousa1,Silva Francilene Vieira da1ORCID,Fernandes Hélio de Barros12ORCID,Sousa Damião Pergentino de3ORCID,Oliveira Rita de Cássia Meneses12,Arcanjo Daniel Dias Rufino2ORCID,Martins Maria do Carmo de Carvalho e12ORCID

Affiliation:

1. Medicinal Plants Research Center, Federal University of Piauí, Teresina, PI, Brazil

2. Department of Biophysics and Physiology, Federal University of Piauí, Teresina, PI, Brazil

3. Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, PB, Brazil

Abstract

Menthofuran is a monoterpene present in various essential oils derived from species from Mentha genus, and in Brazil, those species are widely used in treating gastrointestinal and respiratory disorders. Considering the wide pharmacological potential of monoterpenes, including their antioxidant activity, this study aimed to evaluate menthofuran-gastroprotective activity, as well as the involvement of antioxidant mechanisms in this effect. The acute toxicity was evaluated according to the fixed dose method. The antiulcerogenic activity was investigated by using experimental models of gastric ulcers induced by ethanol, indomethacin, and ischemia/reperfusion in rats. The antisecretory gastric activity, the catalase activity, and the gastric wall mucus were determined in pylorus ligated rats. Gastric wall nonprotein sulfhydryl (NPSH) group content, myeloperoxidase (MPO) activity, and malondialdehyde (MDA) content were evaluated in ethanol-induced the gastric ulcer model. Menthofuran (2 g/kg) presented low acute toxicity and showed gastroprotective activity against ethanol-, indomethacin-, and ischemia/reperfusion-induced ulcers. Moreover, menthofuran presented antisecretory activity, reduced the total acidity, and increased pH of gastric secretion. On the other hand, a decrease in mucus content of gastric wall without alteration of gastric juice volume and catalase activity was observed. Interestingly, menthofuran increased NPSH levels and reduced MDA levels and MPO activity. Gastroprotective effects of menthofuran appear to be mediated, at least in part, by the NOS pathway, endogenous prostaglandins, reduced gastric juice acidity, increased concentration of the NPSH groups, and reduced lipidic peroxidation. These findings support the menthofuran as an effective gastroprotective agent, as well as the marked participation of antioxidant mechanisms in this response.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

Reference61 articles.

1. Guías clínicas de diagnóstico y tratamiento de la enfermedad por úlcera péptica. Generalidades (2014);C. R. Raña;Revista de Gastroenterología de México,2014

2. Diagnosis and treatment of peptic ulcer disease and H. pylori infection;J. P. Fashner;American Family Physician,2015

3. Gastric Mucosal Defense and Cytoprotection: Bench to Bedside

4. Experimental gastric mucosal injury: laboratory models reveal mechanisms of pathogenesis and new therapeutic strategies

5. Fármacos para controle da acidez gástrica e tratamento de úlceras pépticas;K. A. Sharkey,2018

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