Deep Learning-Based Computed Tomography Perfusion Imaging to Evaluate the Effectiveness and Safety of Thrombolytic Therapy for Cerebral Infarct with Unknown Time of Onset

Abstract

This study was aimed to discuss the effectiveness and safety of deep learning-based computed tomography perfusion (CTP) imaging in the thrombolytic therapy for acute cerebral infarct with unknown time of onset. A total of 100 patients with acute cerebral infarct with unknown time of onset were selected as the research objects. All patients received thrombolytic therapy. According to different image processing methods, they were divided into the algorithm group (artificial intelligence algorithm-based image processing group) and the control group (conventional method-based image processing group). After that, the evaluations of effectiveness and safety of thrombolytic therapy for the patients with acute cerebral infarct in the two groups were compared. The research results demonstrated that artificial intelligence algorithm-based CTP imaging showed significant diagnostic effects and the image quality in the algorithm group was remarkably higher than that in the control group ( $P<0.05$ ). Besides, the overall image quality of algorithm group was relatively higher. The differences in the National Institute of Health stroke scale (NIHSS) scores for the two groups indicated that the thrombolytic effect on the algorithm group was superior to that on the control group. Thrombolytic therapy for the algorithm group showed therapeutic effects on neurologic impairment. The symptomatic intracranial hemorrhage rate of the algorithm group within 24 hours was lower than the hemorrhage conversion rate of the control group, and the difference between the two groups was 14%. The data differences between the two groups showed statistical significance ( $P<0.05$ ). The results demonstrated that the safety of guided thrombolytic therapy for the algorithm group was higher than that in the control group. To sum up, deep learning-based CTP images showed the clinical application values in the diagnosis of cerebral infarct.