Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman-Reference-Cited by-同舟云学术

Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman

Published:2019-09-22 Issue: Volume:2019 Page:1-5
ISSN:2090-6501
Container-title:Case Reports in Endocrinology
language:en
Short-container-title:Case Reports in Endocrinology

Author:

Catteau Aurore¹,Bach-Ngohou Kalyane¹²,Blin Justine¹²,Barrière Paul²³,Fréour Thomas²³,Masson Damien¹²^ORCID

Affiliation:

1. Laboratoire de biochimie, Institut de Biologie, CHU de Nantes, Nantes, France

2. Faculté de médecine, Université de Nantes, Nantes, France

3. Service de médecine et biologie du développement et de la reproduction, CHU de Nantes, Nantes, France

Abstract

We report a case of 33-year-old woman with a 4-year primary infertility. A high isolated follicle-stimulating hormone (FSH) level was conflicting with the clinical situation and with other hormonal markers which were in favor of polycystic ovarian syndrome. We followed a strategy used to identify immune complexes involving FSH. The PEG precipitation test revealed that the high FSH level was almost exclusively due to the presence of autoimmune FSH immunoglobulin complex (macro-FSH). The profile obtained by gel filtration chromatography confirmed the presence of an FSH-immunoglobulin complex. Such immunological dysregulation could be explored in cases of unexplained infertility and recurrent IVF failure.

Publisher

Hindawi Limited

Subject

Endocrinology, Diabetes and Metabolism

Link

http://downloads.hindawi.com/journals/crie/2019/3071649.pdf

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