Hormonal and Sex Impact on the Epidemiology of Canine Lymphoma

Author:

Villamil J. Armando1,Henry Carolyn J.12,Hahn Allen W.1,Bryan Jeffrey N.3,Tyler Jeff W.14,Caldwell Charles W.5

Affiliation:

1. Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, MO 65211, USA

2. Hematology/Oncology Division, Department of Internal Medicine, University of Missouri, Columbia, MO 65211, USA

3. Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 99164, USA

4. Department of Veterinary Medicine and Surgery, University of Missouri Public Health Program, University of Missouri, Columbia, MO 65211, USA

5. Department of Pathology and Anatomical Sciences, School of Medicine and Ellis Fischel Cancer Center, University of Missouri, Columbia, MO 65211, USA

Abstract

The Surveillance Epidemiology and End Results data demonstrate that the risk of non-Hodgkin lymphoma is lower for women, but that the incidence increases after fifty years of age, at which menopause is regularly reached, suggesting that female hormones may be protective for NHL. This study examines the influence of sex on lymphoma risk in a relevant large animal model. Records for dogs in the Veterinary Medical Database were analyzed from 1964 to 2002. Risk ratios were calculated to evaluate associations between sex, neutering status, and lymphoma occurrence. A total of 14,573 cases and 1,157,342 controls were identified. Intact females had a significantly lower risk of developing lymphoma, Odds Ratio 0.69 (0.63–0.74) with aP<.001. We conclude that there is a sex effect on NHL risk in dogs similar to humans. We hypothesize that the hormone levels of intact females lower the risk of NHL. The possibility of a protective role of endogenous estrogens in the etiology of NHL should be investigated.

Funder

U.S. National Library of Medicine

Publisher

Hindawi Limited

Subject

Public Health, Environmental and Occupational Health,Genetics,Epidemiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3