Muscle Fiber Diameter and Density Alterations after Stroke Examined by Single-Fiber EMG

Abstract

This study presents single-fiber electromyography (EMG) analysis for assessment of paretic muscle changes after stroke. Single-fiber action potentials (SFAPs) were recorded from the first dorsal interosseous (FDI) muscle bilaterally in 12 individuals with hemiparetic stroke. The SFAP parameters, including the negative peak duration and the peak-peak amplitude, were measured and further used to estimate muscle fiber diameter through a model based on the quadratic function. The SFAP parameters, fiber density, and muscle fiber diameter derived from the model were compared between the paretic and contralateral muscles. The results show that SFAPs recorded from the paretic muscle had significantly smaller negative peak duration than that from the contralateral muscle. As a result, the derived muscle fiber diameter of the paretic muscle was significantly smaller than that of the contralateral muscle. The fiber density of the paretic muscle was significantly higher than that of the contralateral muscle. These results provide further evidence of remodeled motor units after stroke and suggest that paretic muscle weakness can be due to both complex central and peripheral neuromuscular alterations.