Brazilian Green Propolis Compared to Miconazole Gel in the Treatment ofCandida-Associated Denture Stomatitis

Abstract

Aim. To evaluate the efficacy of Brazilian green propolis in comparison to miconazole gel in the treatment ofCandida-associated denture stomatitis.Methods. Forty-five denture stomatitis patients, with palatal mucosa erythema levels classified according to Newtons’s criteria and with positive culture toCandidaspp., were randomly divided into three treatment groups: 15 received miconazole gel 2%, 15 received propolis gel 2,5%, and 15 received propolis 24% for mouthwash. After four daily use lasting two weeks, they were reexamined for the denture stomatitis degree and for a second culture ofCandida. The Wilcoxon’s test was applied to compare the results of clinical classification of the denture stomatitis and theCandidaspp. colonies numbers, before and after each treatment. The Kruskall-Wallis’s test was used to compare efficacy among the three treatment groups.Results. There were a significant reduction or complete remission of denture stomatitis(P<0.05)and a significant decrease ofCandidacolonies for the three groups(P<0.05).There was no difference in the efficacy among the treatment groups(P>0.05).Conclusion. Brazilian green propolis has a similar effect as miconazole in the treatment ofCandida-associated denture stomatitis being an alternative in the therapeutics of this condition.