Potential Use ofEuphorbia hirtafor Dengue: A Systematic Review of Scientific Evidence

Abstract

Euphorbia hirtacommonly known asTawa-Tawais a plant used in folklore medicine in the Philippines for the treatment of dengue. Though,E. hirtahas been extensively investigated for numerous bioactivities, limited studies have been conducted on the antidengue activity. Thus, the present study provides a comprehensive review of studies conducted on the antidengue activity ofE. hirta. A systematic literature survey was carried out in scientific databases, PubMed®, Scopus, and Google Scholar, for research carried on the antidengue activity ofE. hirta. The literature search identified a total of 867 articles: databases PubMed = 6, Scopus SciVerse® = 423, and Google Scholar = 437; one additional article was identified by searching reference lists. Eight full papers were entitled to the review; out of those, two studies focused on ethnobotanical surveys, three on animal experiments, one on human trial, and two onin vitroantiviral activities, and one was computational study. The available evidence conclusively demonstrates the potential ofE. hirtaagainst dengue as it holds significant antiviral and platelet increasing activities. However, the number of studies conducted to validate its antidengue activity was found to be inadequate. Hence, well-controlled clinical trials and contemporary pharmacological approaches including activity guided fractionation and elucidation of the mode of action are encouraged to establish the use ofE. hirtafor dengue.