Chondro-Osseous Metaplasia in Ependymoma: A Rare Histopathological Finding

Author:

Alkhaibary Ali123ORCID,AlSufiani Fahd24,Alassiri Ali H.124,Almuntashri Makki125,Al Qutub Salma Tarik6

Affiliation:

1. College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

2. King Abdullah International Medical Research Center, Riyadh, Saudi Arabia

3. Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia

4. Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia

5. Medical Imaging Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia

6. Diagnostic Neuroradiology Department, King Faisal Specialist Hospital, Dr. Fakeeh Hospital, Jeddah, Saudi Arabia

Abstract

Ependymoma is a circumscribed glioma composed of uniform glial cells with bland nuclei in a fibrillary matrix. It is characterized by the presence of perivascular pseudorosettes. Unusual histopathological findings have rarely been reported in ependymomas, 0.5% of all diagnosed cases. Such unusual and exceedingly rare histological findings include osseous or chondroid metaplasia. To the best of our knowledge, only 15 cases of osseocartilaginous ependymomas have been reported in English literature. We report a 3-year-old boy who presented with ataxia, vomiting, and headache for three months. Radiological imaging revealed a posterior fossa lesion. Histopathological examination of the lesion confirmed a posterior fossa ependymoma with chondro-osseous metaplasia. The present case outlines the clinical presentation, histopathological findings, and outcome of chondro-osseous metaplasia in ependymomas. To date, the etiology of chondro-osseous metaplasia in ependymomas remains uncertain. Further research exploring such phenomenon is of paramount importance to explain how these tumors develop.

Publisher

Hindawi Limited

Subject

General Medicine

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