Complexes With Biologically Active Ligands. Part 61 Ni(II) Coordination Compounds of Hydrazine and Heterocyclic Sulfonamides as Inhibitors of the Zinc Enzyme Carbonic Anhydrase-Reference-Cited by-同舟云学术

Complexes With Biologically Active Ligands. Part 61 Ni(II) Coordination Compounds of Hydrazine and Heterocyclic Sulfonamides as Inhibitors of the Zinc Enzyme Carbonic Anhydrase

Published:1996-01-01 Issue:3 Volume:3 Page:143-148
ISSN:0793-0291
Container-title:Metal-Based Drugs
language:en
Short-container-title:Metal-Based Drugs

Author:

Borràs Joaquin¹,Casanova Javier¹,Cristea Teodora²,Gheorghe Adriana²,Scozzafava Andrea³,Supuran Claudiu T.³,Tudor Violeta²

Affiliation:

1. University of Valencia, Faculty of Pharmacy, Department of Inorganic Chemistry, Vincent Andres Estelles s/n, Burjassot (Valencia) E-46100, Spain

2. University of Bucharest, Department of Chemistry, Bd. Carol I (Republicii) 13, Bucharest R-70346, Romania

3. University of Florence, Laboratory of Inorganic and Bioinorganic Chemistry, Via Gino Capponi 7, Firenze I-50121, Italy

Abstract

Ternary Ni(II) complexes of hydrazine and eight heterocyclic sulfonamides possessing carbonic anhydrase (CA) inhibitory properties, were prepared and characterized by elemental analysis, spectroscopic, magnetic, thermogravimetric, and conductimetric measurements. The complexes behave as strong inhibitors for two isozymes (I and II) of carbonic anhydrase.

Publisher

Hindawi Limited

Subject

Inorganic Chemistry,Drug Discovery,Pharmacology,Toxicology

Link

http://downloads.hindawi.com/archive/1996/724234.pdf

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