Detection of the Hematopoietic Stem and Progenitor Cell Marker CD133 during Angiogenesis in Three-Dimensional Collagen Gel Culture-Reference-Cited by-同舟云学术

Detection of the Hematopoietic Stem and Progenitor Cell Marker CD133 during Angiogenesis in Three-Dimensional Collagen Gel Culture

Published:2013 Issue: Volume:2013 Page:1-10
ISSN:1687-966X
Container-title:Stem Cells International
language:en
Short-container-title:Stem Cells International

Author:

Akita Masumi¹^ORCID,Tanaka Kayoko¹,Matsumoto Sachiko¹,Komatsu Kumiko¹,Fujita Keiko²

Affiliation:

1. Division of Morphological Science, Biomedical Research Center, Saitama Medical University, 38 Moroyama, Iruma-gun, Saitama 350-0495, Japan

2. Department of Anatomy, Saitama Medical University, 38 Moroyama, Iruma-gun, Saitama 350-0495, Japan

Abstract

We detected the hematopoietic stem and progenitor cell marker CD133 using immunogold labeling during angiogenesis in a three-dimensional collagen gel culture. CD133-positive cells were present in capillary tubes newly formed from aortic explants in vitro. The CD133-positive cell population had the capacity to form capillary tubes. Lovastatin strongly inhibited cell migration from aortic explants and caused the degradation of the capillary tubes. The present study provides insight into the function of CD133 during angiogenesis as well as an explanation for the antiangiogenic effect of statins.

Funder

Japan Society for the Promotion of Science

Publisher

Hindawi Limited

Subject

Cell Biology,Molecular Biology

Link

http://downloads.hindawi.com/journals/sci/2013/927403.pdf

Reference49 articles.

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