Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant-Reference-Cited by-同舟云学术

Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant

Published:2013 Issue: Volume:2013 Page:1-3
ISSN:2090-682X
Container-title:Case Reports in Psychiatry
language:en
Short-container-title:Case Reports in Psychiatry

Author:

Bersani Giuseppe¹,Marino Pietropaolo¹²,Valeriani Giuseppe¹²^ORCID,Cuoco Valentina¹^ORCID,Zitelli Claudia¹,Melcore Claudia¹,Bersani Francesco Saverio¹²

Affiliation:

1. Department of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, Italy

2. Department of Neurology and Psychiatry, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, Italy

Abstract

Several neurological side effects induced by tacrolimus are described in the scientific literature, ranging from mild neurological symptoms to delirium and psychosis. We report the case of a 46-year-old man with no prior psychiatric history who suddenly manifested manic-like psychosis associated with elevated trough tacrolimus blood concentrations 17 years after kidney transplant. The use of antipsychotics may improve the severity of symptoms; but in order to obtain a complete remission, the reduction in the dose of tacrolimus, or its replacement with alternative immunosuppressant therapies, is recommended.

Publisher

Hindawi Limited

Subject

Psychiatry and Mental health

Link

http://downloads.hindawi.com/journals/crips/2013/926395.pdf

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