Efficacy and Safety of Echinacoside in a Rat Osteopenia Model

Author:

Yang Xiaolin1,Li Fei2,Yang Yanan3,Shen Jinyang2,Zou Run2,Zhu Panpan2,Zhang Chunfeng2,Yang Zhonglin2,Li Ping2

Affiliation:

1. Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China

2. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China

3. Institute of Materia Medica, Shanghai No.1 Biochemical & Pharmaceutical Company Ltd., Shanghai 200240, China

Abstract

This study aimed to investigate the efficacy and safety of echinacoside (ECH) using an osteopenia rat model. Forty-eight 6-month-old female Sprague-Dawley rats were randomly divided into one sham-operated group (SHAM) and five OVX (ovariectomized) subgroups: SHAM with vehicle 0.5% carboxymethylcellulose sodium (0.5% CMC-Na) and OVX with vehicle (OVX), OVX with 17β-estradiol (E2), and OVX with ECH of graded doses (ECH-L, ECH-M, and ECH-H). The effects of ECH and E2 on serum biochemical parameters, bone mineral density (BMD), bone biomechanical properties, bone microarchitecture, and immunohistochemistry were examined, and safety assessments were also evaluated. The results showed that ECH treatments improved total femur BMD, bone microarchitecture, and biomechanical properties and decreased serum marker levels in comparison to OVX group. Moreover, ECH administration significantly increased osteoprotegerin (OPG) level, and decreased receptor activator of nuclear factor-κB ligand (RANKL) level in serum, as well as in proximal femur. Importantly, ECH treatment ameliorated the lipid parameters without the overall incidences of adverse events of uterus and mammary gland compared to OVX and SHAM groups. This study demonstrated that administration of ECH for 12 weeks can effectively and safely prevent OVX-induced osteoporosis in rats via increasing the OPG/RANKL ratio.

Funder

Research and Innovation Project Foundation for College Graduates of Jiangsu Province

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

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