Affiliation:
1. Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology, P M B. 704, Akure 340001, Nigeria
Abstract
The antioxidant properties and effect of essential oil of black pepper (Piper guineense) seeds onα-amylase,α-glucosidase (key enzymes linked to type-2 diabetes), and angiotensin-I converting enzyme (ACE) (key enzyme linked to hypertension) were assessed. The essential oil was obtained by hydrodistillation and dried with anhydrous Na2SO4, and the phenolic content, radical [1,1-diphenyl-2 picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) and nitric oxide (NO)] scavenging abilities as well as the ferric reducing antioxidant property (FRAP) and Fe2+-chelating ability of the essential oil were investigated. Furthermore, the effect onα-amylase,α-glucosidase, and ACE enzyme activities was also investigated. The characterization of the constituents was done using GC. The essential oil scavenged DPPH*, NO*, and ABTS* and chelated Fe2+.α-Pinene,β-pinene, cis-ocimene, myrcene, allo-ocimene, and 1,8-cineole were among the constituents identified by GC. The essential oil inhibitedα-amylase,α-glucosidase, and ACE enzyme activities in concentration-dependent manners, though exhibiting a stronger inhibition ofα-glucosidase thanα-amylase activities. Conclusively, the phenolic content, antioxidant activity, and inhibition ofα-amylase,α-glucosidase, and angiotensin-1 converting enzyme activities by the essential oil extract of black pepper could be part of the mechanism by which the essential oil could manage and/or prevent type-2 diabetes and hypertension.
Subject
Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine
Cited by
47 articles.
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