Synthesis, Characterization and In vitro Antitumour Activity of Novel Organotin Derivatives of 1,2- and 1,7-Dicarba-Closo-dodecaboranes-Reference-Cited by-同舟云学术

Synthesis, Characterization and In vitro Antitumour Activity of Novel Organotin Derivatives of 1,2- and 1,7-Dicarba-Closo-dodecaboranes

Published:1995-01-01 Issue:1 Volume:2 Page:37-42
ISSN:0793-0291
Container-title:Metal-Based Drugs
language:en
Short-container-title:Metal-Based Drugs

Author:

Gielen Marcel¹,Kayser François¹²,Zhidkova Olga B.³,Kampel Vladimir Ts.³,Bregadze Vladimir l.³,de Vos Dick⁴,Biesemans Monique¹²,Mahieu Bernard⁵,Willem Rudolph¹²

Affiliation:

1. Free University of Brussels, VUB, Department of General and Organic Chemistry, Faculty of Engineering, Room 8G512, Brussels, Belgium

2. Room 8G512, High Resolution NMR Centre, HNMR, Pleinlaan 2, Brussels B-1050, Belgium

3. A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow 117813, Russia

4. Pharmachemie BV, Medical Department, Haarlem NL-2003 RN, Netherlands Antilles

5. Catholic University of Louvain, INAN, Louvain-la-Neuve, Belgium

Abstract

Several organotin derivatives of 1,2- and 1,7-dicarba-closo-dodecaboranes were synthesized and characterized by S119n Mössbauer, H1 , C13 and S119n NMR spectroscopy. Their antitumour activities in vitro against cancerous cell lines of human origin are reported.

Publisher

Hindawi Limited

Subject

Inorganic Chemistry,Drug Discovery,Pharmacology,Toxicology

Link

http://downloads.hindawi.com/archive/1995/452473.pdf

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