Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience

Author:

Buechter Matthias1,Manka Paul12,Heinemann Falko Markus3,Lindemann Monika3,Juntermanns Benjamin4,Canbay Ali1,Gerken Guido1,Kahraman Alisan1ORCID

Affiliation:

1. Department of Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany

2. Division of Transplantation Immunology and Mucosal Biology, King’s College London, London, UK

3. Institute of Transfusion Medicine, University Hospital Essen, Essen, Germany

4. Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Essen, Germany

Abstract

Introduction. Most investigations on autoimmune pancreatitis (AIP) were published on Asian cohorts while those on Caucasians are limited. However, there might be differences related to the origin.Patients and Methods. We analyzed 36 patients and compared type 1 (AIP1) with type 2 (AIP2).Results. The majority of patients suffered from AIP1 (55.6%). AIP1 patients were significantly older than AIP2 patients (54.4 versus 40.8 years). Moreover, 85.0% of AIP1 patients had concurrent autoimmune cholangitis (AIC) while 18.8% of AIP2 patients suffered from overlap to ulcerative colitis (UC). However, AIP1 patients revealed a cholestatic course and had significantly higher immunoglobulin G4 levels (IgG4). When compared to allele frequencies in healthy controls, in patients with AIP1 HLA-B8 reached statistical significance. Response to steroids was excellent in both groups, but we noticed high rates of relapse especially in AIP1 patients. Finally, 3 patients with AIP1 were diagnosed with cholangiocellular carcinoma (CCC).Conclusion. In contrast to Asian studies, we found an almost equal distribution of AIP1 and AIP2 patients in our German cohort. AIP2 patients were younger and mostly of female gender whereas AIP1 patients revealed higher IgG4 levels and involvement of the biliary tract in sense of IgG4-associated cholangitis.

Publisher

Hindawi Limited

Subject

Gastroenterology,Hepatology

Cited by 18 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Autoimmune pancreatitis;The Rose and Mackay Textbook of Autoimmune Diseases;2024

2. Type 2 autoimmune pancreatitis associated with ulcerative colitis;Frontiers in Immunology;2023-12-06

3. Diagnostic utility of serum IgG4 level in IgG4-related diseases: a comprehensive systematic review and meta-analysis;RMD Open;2023-12

4. Long‐Term Outcome After Treatment of Autoimmune Pancreatitis;The Pancreas;2023-08-04

5. IgG4-Related Disease: A Concise Review;Journal of Clinical Rheumatology and Immunology;2023-07

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3