Association of the Composite Inflammatory Biomarker GlycA, with Exercise-Induced Changes in Body Habitus in Men and Women with Prediabetes

Author:

Bartlett David B.12ORCID,Slentz Cris A.1,Connelly Margery A.3,Piner Lucy W.1,Willis Leslie H.1,Bateman Lori A.1,Granville Esther O.1,Bales Connie W.14,Huffman Kim M.14,Kraus William E.15

Affiliation:

1. Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA

2. Division of Medical Oncology, Department of Medicine, Duke University, Durham, NC, USA

3. LipoScience, Laboratory Corporation of America Holdings, Morrisville, NC, USA

4. Physical Medicine and Rehabilitation Service, Veterans Affairs Medical Center, Durham, NC, USA

5. Division of Cardiology Medicine, Duke University Medical Center, Durham, NC, USA

Abstract

GlycA is a new composite measure of systemic inflammation and a predictor of many inflammatory diseases. GlycA is the nuclear magnetic resonance spectroscopy-derived signal arising from glucosamine residues on acute-phase proteins. This study aimed to evaluate how exercise-based lifestyle interventions modulate GlycA in persons at risk for type 2 diabetes. GlycA, fitness, and body habitus were measured in 169 sedentary adults (45–75 years) with prediabetes randomly assigned to one of four six-month exercise-based lifestyle interventions. Interventions included exercise prescription based on the amount (energy expenditure (kcal/kg weight/week (KKW)) and intensity (%VO2peak). The groups were (1) low-amount/moderate-intensity (10KKW/50%) exercise; (2) high-amount/moderate-intensity (16KKW/50%) exercise; (3) high-amount/vigorous-intensity (16KKW/75%) exercise; and (4) a Clinical Lifestyle (combined diet plus low-amount/moderate-intensity exercise) intervention. Six months of exercise training and/or diet-reduced GlycA (mean Δ: −6.8 ± 29.2 μmol/L;p=0.006) and increased VO2peak(mean Δ: 1.98 ± 2.6 mL/kg/min;p<0.001). Further, visceral (mean Δ: −21.1 ± 36.6 cm2) and subcutaneous fat (mean Δ: −24.3 ± 41.0 cm2) were reduced, while liver density (mean Δ: +2.3 ± 6.5HU) increased, allp<0.001. When including individuals in all four interventions, GlycA reductions were associated with reductions in visceral adiposity (p<0.03). Exercise-based lifestyle interventions reduced GlycA concentrations through mechanisms related to exercise-induced modulations of visceral adiposity. This trial is registered with Clinical Trial Registration Number NCT00962962.

Funder

LipoScience, Inc.

Publisher

Hindawi Limited

Subject

Cell Biology,Aging,General Medicine,Biochemistry

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