Number of Polyploid Giant Cancer Cells and Expression of EZH2 Are Associated with VM Formation and Tumor Grade in Human Ovarian Tumor

Author:

Zhang Li1,Ding Po2,Lv Hongcheng1,Zhang Dan1,Liu Guang1,Yang Zhengduo1,Li Yan3,Liu Jun4,Zhang Shiwu1ORCID

Affiliation:

1. Department of Pathology, Tianjin Union Medicine Center, Tianjin 300121, China

2. Department of General Surgery, Tianjin Union Medicine Center, Tianjin 300121, China

3. Department of Gynaecology and Obstetrics, Tianjin Union Medicine Center, Tianjin 300121, China

4. Department of Medical Imaging, Tianjin Union Medicine Center, Tianjin 300121, China

Abstract

To investigate the associations among the number of polyploid giant cancer cells (PGCCs) and vasculogenic mimicry (VM), EZH2 expression, and serous ovarian tumor grade, a total of 80 paraffin-embedded serous ovarian tumor samples including 21 cases of primary carcinoma and their metastatic tumors, 26 cases of primary carcinoma without metastasis, and 12 cases of serous borderline cystadenoma were analyzed. PGCCs and VM were detected in human serous ovarian tumor. The metastatic foci of ovarian carcinoma had the highest number of PGCCs and VM. The number of PGCCs and VM increased with the grade of ovarian carcinomas. PGCCs generated erythrocytes via budding and together they formed VM. Tumor cells and cancer-associated fibroblasts were positive for EZH2 immunohistochemical staining. The tumor cells and cancer associated fibroblasts in the metastatic foci had the highest staining index of EZH2 staining. Both tumor cells and cancer-associated fibroblasts express EZH2 which then contributes to the malignant grade of serous ovarian tumor.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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