Vomiting and Dysphagia Predict Delayed Gastric Emptying in Diabetic and Nondiabetic Subjects

Abstract

Background.Gastroparesis is a heterogeneous disorder most often idiopathic, diabetic, or postsurgical in nature. The demographic and clinical predictors of gastroparesis in Israeli patients are poorly defined.Methods.During the study period we identified all adult patients who were referred to gastric emptying scintigraphy (GES) for the evaluation of dyspeptic symptoms. Of those, 193 patients who were referred to GES from our institution were retrospectively identified (76 (39%) males, mean age60.2±15.6years). Subjects were grouped according to gastric half-emptying times (gastricT1/2). Demographic and clinical data were extracted from electronic medical records or by a phone interview.Key Results.Gastric emptying half-times were normal (gastricT1/20–99 min) in 101 patients, abnormal (gastricT1/2100–299 min) in 67 patients, and grossly abnormal (gastricT1/2≥300 min) in 25 patients. Vomiting and dysphagia, but neither early satiety nor bloating, correlated with delayed gastric emptying. Diabetes was associated with grossly abnormal gastricT1/2. Idiopathic gastroparesis was associated with a younger age at GES. No correlation was observed between gastricT1/2values and gender, smoking,H. pyloriinfection, HBA1C, or microvascular complication of diabetes.Conclusions Inferences.Vomiting and dysphagia are predictive of delayed gastric emptying in both diabetic and nondiabetic subjects. Diabetes is associated with more severe gastroparesis.