Robocasting of Bioactive SiO2-P2O5-CaO-MgO-Na2O-K2O Glass Scaffolds

Author:

Baino Francesco1ORCID,Barberi Jacopo1,Fiume Elisa12,Orlygsson Gissur3,Massera Jonathan4,Verné Enrica1

Affiliation:

1. Department of Applied Science and Technology (DISAT), Politecnico di Torino, Turin, Italy

2. Department of Mechanical and Aerospace Engineering (DIMEAS), Politecnico di Torino, Turin, Italy

3. Department of Materials, Biotechnology and Energy, Innovation Center Iceland (ICI), Reykjavik, Iceland

4. Faculty of Medicine and Health Technology, University of Tampere, Tampere, Finland

Abstract

Bioactive silicate glass scaffolds were fabricated by a robocasting process in which all the movements of the printing head were programmed by compiling a script (text file). A printable ink made of glass powder and Pluronic F-127, acting as a binder, was extruded to obtain macroporous scaffolds with a grid-like three-dimensional structure. The scaffold architecture was investigated by scanning electron microscopy and microtomographic analysis, which allowed quantifying the microstructural parameters (pore size 150–180 μm and strut diameter 300 μm). In vitro tests in simulated body fluid (SBF) confirmed the apatite-forming ability (i.e., bioactivity) of the scaffolds. The compressive strength (around 10 MPa for as-produced scaffolds) progressively decreased during immersion in SBF (3.3 MPa after 4 weeks) but remains acceptable for bone repair applications. Taken together, these results (adequate porosity and mechanical strength as well as bioactivity) support the potential suitability of the prepared scaffolds for bone substitution.

Funder

Academy of Finland

Publisher

Hindawi Limited

Subject

Health Informatics,Biomedical Engineering,Surgery,Biotechnology

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