Integrated Stress Response as a Therapeutic Target for CNS Injuries-Reference-Cited by-同舟云学术

Integrated Stress Response as a Therapeutic Target for CNS Injuries

Published:2017 Issue: Volume:2017 Page:1-7
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Romero-Ramírez Lorenzo¹^ORCID,Nieto-Sampedro Manuel¹²,Barreda-Manso M. Asunción³

Affiliation:

1. Unidad de Neurología Experimental, Hospital Nacional de Parapléjicos (SESCAM), Finca la Peraleda s/n, 45071 Toledo, Spain

2. Departamento de Neurobiología Funcional y de Sistemas, Laboratorio de Plasticidad Neural, Instituto Cajal (CSIC), Avenida Doctor Arce 37, 28002 Madrid, Spain

3. Laboratorio de Endocannabinoides y Neuroinflamación, School of Biosciences, Universidad Francisco de Vitoria, 28223 Pozuelo de Alarcón, Madrid, Spain

Abstract

Central nervous system (CNS) injuries, caused by cerebrovascular pathologies or mechanical contusions (e.g., traumatic brain injury, TBI) comprise a diverse group of disorders that share the activation of the integrated stress response (ISR). This pathway is an innate protective mechanism, with encouraging potential as therapeutic target for CNS injury repair. In this review, we will focus on the progress in understanding the role of the ISR and we will discuss the effects of various small molecules that target the ISR on different animal models of CNS injury.

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2017/6953156.pdf

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2. NADPH Oxidase Plays a Central Role in Blood-Brain Barrier Damage in Experimental Stroke

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