Epidemiological Characterization of Drug Resistance amongMycobacterium tuberculosisIsolated from Patients in Northeast of Iran during 2012-2013

Abstract

Introduction. Tuberculosis is still one of the most important health problems in developing countries and increasing drug resistance is the main concern for its treatment. This study was designed to characterize the drug resistantMycobacterium tuberculosisisolated from patients suffering from pulmonary tuberculosis in northeast of Iran.Method. In this cross-sectional study during 2012-2013, drug susceptibility testing was performed onMycobacterium tuberculosisisolated in northeast of Iran using proportional method. Epidemiological data concerning these strains were also analyzed.Results. Among 125 studied isolates, 25 mycobacteria (20%) were diagnosed as nontuberculosis mycobacteria. Among the remaining 100Mycobacterium tuberculosisisolates, the resistance rates were 7%, 7%, 3%, and 9% against isoniazid, rifampin, ethambutol, and streptomycin, respectively. Four isolates were resistant against both isoniazid and rifampin (MDR tuberculosis). The highest resistance rate was observed among 15–45-year-old patients. The MDR tuberculosis was much more prevalent among those who had previous history of treatment.Conclusion. Considering these findings, DOTS strategy should be emphasized and promptly used in order to prevent further resistance. Regarding the high rate of nontuberculosis mycobacteria, it is recommended that confirmatory tests were performed before any therapeutic decision.