Markers of Oral Lichen Planus Malignant Transformation-Reference-Cited by-同舟云学术

Markers of Oral Lichen Planus Malignant Transformation

Published:2018 Issue: Volume:2018 Page:1-13
ISSN:0278-0240
Container-title:Disease Markers
language:en
Short-container-title:Disease Markers

Author:

Tampa Mircea¹²,Caruntu Constantin³⁴^ORCID,Mitran Madalina¹²,Mitran Cristina¹²,Sarbu Isabela²^ORCID,Rusu Laura-Cristina⁵^ORCID,Matei Clara²,Constantin Carolina⁶⁷^ORCID,Neagu Monica⁶⁷⁸^ORCID,Georgescu Simona-Roxana¹²

Affiliation:

1. “Victor Babes” Clinical Hospital for Infectious Diseases, 281 Mihai Bravu, 030303 Bucharest, Romania

2. “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu, 020021 Bucharest, Romania

3. Department of Physiology, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari, 050474 Bucharest, Romania

4. Department of Dermatology, “Prof. N. Paulescu” National Institute of Diabetes, Nutrition and Metabolic Diseases, 22-24 Gr. Manolescu, 011233 Bucharest, Romania

5. Oral Pathology Department, Faculty of Dentistry, “Victor Babeș” University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania

6. Immunology Department, “Victor Babes” National Institute of Pathology, 99-101 Spl. Independentei, 050096 Bucharest, Romania

7. Colentina Clinical Hospital, 19-21 Ştefan cel Mare Blv., 020125 Bucharest, Romania

8. Faculty of Biology, University of Bucharest, 91-95 Spl. Independentei, 76201 Bucharest, Romania

Abstract

Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology with significant impact on patients’ quality of life. Malignant transformation into oral squamous cell carcinoma (OSCC) is considered as one of the most serious complications of the disease; nevertheless, controversy still persists. Various factors seem to be involved in the progression of malignant transformation; however, the mechanism of this process is not fully understood yet. Molecular alterations detected in OLP samples might represent useful biomarkers for predicting and monitoring the malignant progression. In this review, we discuss various studies which highlight different molecules as ominous predictors of OLP malignant transformation.

Funder

Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii

Publisher

Hindawi Limited

Subject

Biochemistry (medical),Clinical Biochemistry,Genetics,Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/dm/2018/1959506.pdf

Reference136 articles.

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2. Squamous cell carcinoma development in previously diagnosed oral lichen planus: de novo or transformation?

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