The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)-Reference-Cited by-同舟云学术

The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)

Published:2020-08-04 Issue: Volume:2020 Page:1-16
ISSN:2314-6745
Container-title:Journal of Diabetes Research
language:en
Short-container-title:Journal of Diabetes Research

Author:

Tanase Daniela Maria¹²^ORCID,Gosav Evelina Maria¹²^ORCID,Costea Claudia Florida³⁴,Ciocoiu Manuela⁵^ORCID,Lacatusu Cristina Mihaela⁶⁷,Maranduca Minela Aida⁸,Ouatu Anca¹²^ORCID,Floria Mariana¹⁹^ORCID

Affiliation:

1. Department of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania

2. Internal Medicine Clinic, “Sf. Spiridon” County Clinical Emergency Hospital, Iasi, Romania

3. Department of Ophthalmology, “Grigore T. Popa” University of Medicine and Pharmacy, Romania

4. 2nd Ophthalmology Clinic, “Prof. Dr. Nicolae Oblu” Emergency Clinical Hospital, Iasi, Romania

5. Department of Pathophysiology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania

6. Unit of Diabetes, Nutrition and Metabolic Diseases, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania

7. Clinical Center of Diabetes, Nutrition and Metabolic Diseases, “Sf. Spiridon” County Clinical Emergency Hospital, Iasi, Romania

8. Department of Physiology, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania

9. Internal Medicine Clinic, Emergency Military Clinical Hospital, Iasi, Romania

Abstract

Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and intricate association is supported and mediated by insulin resistance (IR). In this review, we discuss the NAFLD immunopathogenesis, connection with IR and T2DM, the role of screening and noninvasive tools, and mostly the impact of the current antidiabetic drugs on steatosis liver and new potential therapeutic targets.

Publisher

Hindawi Limited

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

Link

http://downloads.hindawi.com/journals/jdr/2020/3920196.pdf

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