Clinical Application of Rapid Assay of Interleukin-6 in Influenza-Associated Encephalopathy

Author:

Nakamura Mikage1,Yamanaka Gaku1,Kawashima Hisashi1,Watanabe Yoshiaki1,Ioi Hiroaki1,Kashiwagi Yasuyo1,Takekuma Kouji1,Hoshika Akinori1,Hayakawa Mizuho2,Suzuki Shigeru2

Affiliation:

1. Department of Paediatrics, Tokyo Medical University, Japan

2. Department of Central Clinical Laboratory, Tokyo Medical University, Japan

Abstract

The characteristics of influenza-associated encephalopathy is the high mortality and nimble progress with coma which appears in general cases within 48 hours. Most of patients show no abnormalities in the standard blood checks on admission or in early stage. In this study we investigated if a rapid assay of interleukin (IL)-6 is useful in influenza-associated encephalopathy in early stages. The levels of IL-6 in patients with influenza-associated encephalopathy did not show any significant difference compared with those in patients with febrile convulsion and rotavirus-associated convulsion. However the levels of IL-6 in severe cases were significantly higher than those of mild cases with influenza-associated encephalopathy. Consequently the rapid assay of serum IL-6 is useful to evaluate and decide the therapies.

Funder

Ministry of Health, Labour and Welfare

Publisher

Hindawi Limited

Subject

Biochemistry (medical),Clinical Biochemistry,Genetics,Molecular Biology,General Medicine

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