Affiliation:
1. Molecular Nutrition Branch, National Engineering Laboratory for Rice and Byproduct Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004 Hunan, China
Abstract
Epithelial-mesenchymal transition (EMT) is a biological process through which epithelial cells differentiate into mesenchymal cells. EMT plays an important role in embryonic development and wound healing; however, EMT also contributes to some pathological processes, such as tumor metastasis and fibrosis. EMT mechanisms, including gene mutation and transcription factor regulation, are complicated and not yet well understood. In this review, we introduce some herbal active substances that exert antitumor activity through inhibiting EMT that is induced by hypoxia, high blood glucose level, lipopolysaccharide, or other factors.
Funder
Grain-Oil Process and Quality Control 2011 Collaborative and Innovative Grant from Hunan Province
Subject
Cell Biology,Aging,General Medicine,Biochemistry
Cited by
3 articles.
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