Mixed Infections ofHelicobacter pyloriIsolated from Patients with Gastrointestinal Diseases in Taiwan

Author:

Lai Chih-Ho12345ORCID,Huang Ju-Chun34,Chiang-Ni Chuan12,Li Ju-Pi36,Wu Lii-Tzu3,Wu Hua-Shan45,Sun Yu-Chen7,Lin Mei-Ling17,Lee Ju-Fang17,Lin Hwai-Jeng89ORCID

Affiliation:

1. Graduate Institute of Biomedical Sciences, Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan, Taiwan

2. Molecular Infectious Disease Research Center, Department of Pediatrics, Chang Gung Children’s Hospital and Chang Gung Memorial Hospital, Taoyuan, Taiwan

3. Graduate Institute of Basic Medical Science, School of Medicine, China Medical University, Taichung, Taiwan

4. Department of Medical Research and Department of Laboratory Medicine, China Medical University and Hospital, Taichung, Taiwan

5. Department of Nursing, Asia University, Taichung, Taiwan

6. Rheumatology Research Center, China Medical University Hospital, Taichung, Taiwan

7. Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan

8. Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

9. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Shuang-Ho Hospital, New Taipei, Taiwan

Abstract

Background. PersistentHelicobacter pyloriinfection may induce several upper gastrointestinal diseases. Two major virulence factors ofH. pylori, vacuolating cytotoxin A (VacA) and cytotoxin-associated gene A (CagA), are thought to be associated with the severity of disease progression. The distribution ofvacAandcag-pathogenicity island (cag-PAI) alleles varies inH. pyloriisolated from patients in different geographic regions.Aim. To assess the association between mixed infection ofH. pyloriclinical isolates from Taiwanese patients and the severity of gastrointestinal diseases.Methods. A total of 70 patients were enrolled in this study. Six distinct and well-separated colonies were isolated from each patient and 420 colonies were analyzed to determine the genotypes of virulence genes.Results. The prevalence of mixed infections of allH. pylori-infected patients was 28.6% (20/70). The rate of mixed infections in patients with duodenal ulcer (47.6%) was much higher than that with other gastrointestinal diseases (P<0.05).Conclusions.H. pylorimixed infections show high genetic diversity that may enhance bacterial adaptation to the hostile environment of the stomach and contribute to disease development.

Funder

Ministry of Science and Technology

Publisher

Hindawi Limited

Subject

Gastroenterology,Hepatology

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