Novel Organotin(IV)-Schiff Base Complexes: Synthesis, Characterization, Antimicrobial Activity, and DNA Interaction Studies-Reference-Cited by-同舟云学术

Novel Organotin(IV)-Schiff Base Complexes: Synthesis, Characterization, Antimicrobial Activity, and DNA Interaction Studies

Published:2010 Issue: Volume:2010 Page:1-9
ISSN:1565-3633
Container-title:Bioinorganic Chemistry and Applications
language:en
Short-container-title:Bioinorganic Chemistry and Applications

Author:

Prasad K. Shiva¹,Kumar L. Shiva¹,Prasad Melvin²,Revanasiddappa Hosakere D.¹

Affiliation:

1. Department of Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, Karnataka, India

2. Department of Biotechnology, University of Mysore, Manasagangotri, Mysore 570 006, Karnataka, India

Abstract

Four organotin(IV) complexes with 2-(2-hydroxybenzylideneamino)isoindoline-1,3-dione (L1), and 4-(4-hydroxy-3-methoxybenzylideneamino-N-(pyrimidin-2-yl)benzenesulfonamide (L2) were synthesized and well characterized by analytical and spectral studies. The synthesized compounds were tested for antimicrobial activity by disc diffusion method. The DNA binding of the complexes1and3with CT-DNA has been performed with absorption spectroscopy, which showed that both the complexes are avid binders of CT-DNA. Also the nuclease activity of complexes1and3with plasmid DNA (pUC19) was studied using agarose gel electrophoresis. The complex1can act as effective DNA cleaving agent when compared to complex3resulting in the nicked form of DNA under physiological conditions. The gel was run both in the absence and presence of the oxidizing agent.

Publisher

Hindawi Limited

Subject

Inorganic Chemistry,Organic Chemistry,Biochemistry

Link

http://downloads.hindawi.com/journals/bca/2010/854514.pdf

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