Severe Acral Necrosis Complicating Thrombotic Microangiopathy in Two Toddlers

Author:

Nassih H.1ORCID,Lazrak Z.1,Younous S.2

Affiliation:

1. From B Pediatric Ward, Department of Pediatrics, Child and Mother Hospital, Mohammed VI University Hospital Center, Marrakesh Medical and Pharmacy Faculty, Caddy Ayad University, Marrakesh, Morocco

2. From the Pediatric Intensive Care Unit, Department of Pediatrics, Child and Mother Hospital, Mohammed VI University Hospital Center, Marrakesh Medical and Pharmacy Faculty, Caddy Ayad University, Marrakesh, Morocco

Abstract

Acral ischemia/necrosis is one of the rarest but most dreadful complications of thrombotic microangiopathy in pediatric patients. It is more reported with thrombotic thrombocytopenic purpura than with hemolytic and uremic syndrome. Even with anticoagulant therapy, it is often irreversible, leading to amputation.

Publisher

Hindawi Limited

Subject

General Medicine

Reference8 articles.

1. Clinical approach to a patient with isolated digital ischaemia;M. Batra,2002

2. TTP-like syndrome: novel concept and molecular pathogenesis of endotheliopathy-associated vascular microthrombotic disease

3. Concomitant acral necrosis and haemolytic uraemic syndrome following ingestion of quinine;N. Agarwal;Journal of Postgraduate Medicine,2002

4. Foot Manifestations of the Thrombotic Thrombocytopenic Purpura Hemolytic-Uremic Syndrome: A Review and Case Report

5. Various Clinical Manifestations in Patients with Thrombotic Microangiopathy

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