Clinical Relevance of Pharmacogenetics in Serotonin Syndrome

Author:

Pandya Dehuti1ORCID,Tran My2,Verduzco-Gutierrez Monica3ORCID

Affiliation:

1. Department of Pharmacy, TIRR Memorial Hermann Hospital, 1333 Moursund St., Houston TX 77030, USA

2. University of Texas at Austin, College of Pharmacy, 2409 University Ave., Austin TX 78712, USA

3. Department of Rehabilitation Medicine, Joe R. and Teresa Lozano Long School of Medicine at UT Health San Antonio, 7703 Floyd Crule Dr Mail code: 7798, San Antonio, TX 78229, USA

Abstract

Serotonin syndrome is a predictable life-threatening condition that is caused by serotonergic stimulation of the central and peripheral nervous systems. A patient’s genetic profile can amplify exposure risk as many serotonergic drugs are metabolized by CYP450 enzymes, and these enzymes may be altered in functionality. We report a case of an elderly man who presented with serotonin syndrome after a dose change in valproic acid 5 weeks prior. His medication list consisted of low-dose serotonergic agents, which is unusual as most cases of serotonin syndrome involve higher doses. A review of his pharmacogenetic profile is presented to retrospectively evaluate the additive risk for serotonin syndrome and implications on resuming serotonergic agents.

Publisher

Hindawi Limited

Subject

Psychiatry and Mental health

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