Fetal Rat Cerebellar Fragment Transplantation into Adult Rat Forebrain Lesion Cavities

Abstract

Fragments of fetal rat cerebellar tissue were grafted into forebrain cortical lesion cavities of adult rats. After a survival ranging from 12-151 days, no graft was found to fill the cavity completely. Large neurons, occasionally grouped into nests, were identifiable from the 22nd day. Myelinated graft fibers, first seen at 32 days, failed to enter host brain. Although grafts demonstrated elements resembling cerebellar tissue, overall organization did not resemble that of the cerebellum.