Affiliation:
1. Department of Spinal Surgery, Nanjing Lishui People’s Hospital, Nanjing, Jiangsu Province, China
Abstract
Objective. The safety and effectiveness of topical tranexamic acid in spinal surgery has not yet been reached, and further research is needed to confirm it. This study is aimed at detecting the effectiveness and safety on the tranexamic acid in spinal surgery. Methods. The Cochrane Library, PubMed, Embase, CNKI, and other databases were searched. The search time was from 2016 to 2019. All randomized controlled trials comparing the topical tranexamic acid group and the control group were collected. The experimental group used topical application. Tranexamic acid was used to treat bleeding after spinal surgery. The control group was no tranexamic acid or isotonic saline. The total bleeding, blood transfusion rate, and the occurrence of deep vein thrombosis were compared between the two groups. Rev Man 5.2.0 software was used for meta-analysis. Results. A total of 8 randomized controlled trials were included, including 884 patients. Meta-analysis results showed that the total bleeding volume of the tranexamic acid group was lower than that of the control group, and the difference was statistically significant weighted mean difference (
, 95% confidence interval (CI) (–412.68, –307.87) mL,
). The blood transfusion rate in the tranexamic acid group was lower than that in the control group (odds ratio
, 95% CI (0.14, 0.33),
). There was no significant difference in the incidence of deep vein thrombosis between the two groups:
, 95% CI (0.41, 5.34),
. Conclusion. Tranexamic acid can significantly reduce perioperative total blood loss, intraoperative blood loss, and blood transfusion rate during spinal surgery but has no significant effect on blood transfusion and thrombosis.
Funder
Science Foundation of Nanjing Lishui People’s Hospital
Subject
Applied Mathematics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Modeling and Simulation,General Medicine
Reference26 articles.
1. Meta-analysis of the effectiveness and safety of topical tranexamic acid in spinal surgery to reduce postoperative bleeding;L. Yang;Digest of World Latest Medical Information,2019
2. Meta-analysis of the effectiveness and safety of tranexamic acid for hemostasis in spinal surgery;L. Wenjun;Bachu Medicine,2018
3. Meta analysis of the effectiveness and safety of tranexamic acid used in spinal surgery;H. Zhiyong;Modern Practical Medicine,2017
4. Meta analysis of the effectiveness and safety of tranexamic acid in spinal surgery;W. Chao;Chinese Journal of Bone and Joint Surgery,2016
5. Study on the effectiveness and safety of tranexamic acid in elderly hip fracture surgery;L. Xiangping;China Bone and Joint Journal of Injury,2019
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献