Evolution of Metabolic Abnormalities in Alcoholic Patients during Withdrawal

Abstract

Chronic alcohol intoxication is accompanied by metabolic abnormalities. Evolution during the early withdrawal period has been poorly investigated. The aim of this study was to determine the evolution of metabolic parameters during alcohol withdrawal.Patients and Methods. Thirty-three patients admitted in our department for alcohol withdrawal were prospectively included.Results. Baseline hypophosphatemia was found in 24% of cases. FEPO4 was reduced from 14.2 ± 9% at baseline to 7.3 ± 4.2% at day 3 (P<0.01). FEPO4 inversely correlated with albuminemia (rs = −0.41,P= 0.01). CPK level was 124 ± 104 IU/L in men and 145 ± 85 IU/L in women (nl<308and <192 IU/L, resp.), 7% and 28% of patients having a CPK level >nl, respectively. No correlation was found between the sodium and CPK levels (P=0.75) nor between the CPK level and the amount of alcohol ingested (rs = 0.084,P=0.097). Baseline urate level was elevated and returned to normal after three days. Baseline magnesium concentration was normal and stable over time.Conclusion. Chronic alcohol intoxication was accompanied by phosphaturia, rapidly reversible after alcohol withdrawal and inversely correlated with albuminemia, slight hyponatremia, low levels of 25 hydroxy vitamin D, elevated CPK level in about 30% of women, and hyperuricemia with rapid normalization.