Experimental Evaluation of the Pathogenicity of Different Strains ofSchistosoma mansoni

Author:

Euzébio Antônio Aurélio1,Zuim Nádia Regina Borim2,Linhares Arício Xavier2,Magalhães Luiz Augusto2,Zanotti-Magalhães Eliana Maria2

Affiliation:

1. Department of Pediatrics, School of Medical Sciences, State University of Campinas (Unicamp), Rua Tessália Vieira de Camargo, 126 Cidade Universitária Zeferino Vaz, 13083-887 Campinas, SP, Brazil

2. Department of Animal Biology, Institute of Biology, State University of Campinas (Unicamp), Rua Monteiro Lobato, 255 Cidade Universitária Zeferino Vaz, 13083-862 Campinas, SP, Brazil

Abstract

The pathogenesis of three differentSchistosoma mansonistrains from the Brazilian states of Minas Gerais (BH strain) and São Paulo (SJ and SD strains) was evaluated in experimentally infected mice. Observations of the most severe clinical cases among local patients treated (SD strain) in the city of Campinas (São Paulo, Brazil) formed the basis of this study. Mice were used as definitive hosts and were infected with cercariae fromBiomphalaria tenagophila(SJ and SD strains) andBiomphalaria glabrata(BH strains). The parameters analyzed were as follows: number ofS. mansonieggs in mice feces; number of granulomas per tissue area in liver, spleen, lungs, pancreas, and ascending colon; measurements of hepatic and intestinal granulomas; number of adult worms; and measurements of trematode eggs. The comparison among the three strains indicated that the SD strain, isolated in Campinas, presented a higher worm recovery relative to the number of penetrating cercariae. In addition, when compared to the SJ and BH strains, the SD strain demonstrated similar pathogenicity to the BH strain, with a greater quantity of granulomas in the viscera, as well as larger granulomas and eggs. Furthermore, a greater quantity of trematode eggs was also shed in the feces.

Publisher

Hindawi Limited

Subject

Virology,Infectious Diseases,Microbiology (medical),Microbiology,Parasitology

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