Affiliation:
1. 2nd Department of Intensive Care Medicine, “G. Papanikolaou” General Hospital of Thessaloniki, G. Papanikolaou Avenue, Exohi, 57010 Thessaloniki, Greece
2. Department of Cardiothoracic Surgery, “G. Papanikolaou” General Hospital of Thessaloniki, G. Papanikolaou Avenue, Exohi, 57010 Thessaloniki, Greece
Abstract
Purpose. To determine the effect of each of independent acid base variables on the anion gap (AG) value in cardiac surgical patients.Methods. This retrospective study involved 128 cardiac surgical patients admitted for postoperative care. The variation of AG (AGvar) between the day of admission and the first postoperative day was correlated via a multiple linear regression model with the respective variations of the independent acid base variables, that is, apparent strong ion difference (SIDa), strong ion gap (SIG), carbon dioxide (PCO2), and albumin and phosphate concentrations.Results. The variations of all the above variables contributed significantly to the prediction ofAGvar(adjustedR2=0.9999,F=201890.24, andP<0.001). According to the standardized coefficients (β), SIGvar(β= 0.948,P<0.001),[Albumin]var(β= 0.260,P<0.001), and[Phosphate]var(β= 0.191,P<0.001) were the major determinants ofAGvarwith lesser contributions fromSIDa, var(β= 0.071,P<0.001) andPCO2, var(β= −0.067,P<0.001).Conclusions. All the independent acid base variables contribute to the prediction of the AG value. However, albumin and phosphate and SIG variations seem to be the most important predictors, while AG appears to be rather stable with changes in PCO2andSIDa.
Subject
General Environmental Science,General Biochemistry, Genetics and Molecular Biology,General Medicine
Cited by
3 articles.
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