IDH1/IDH2but NotTP53Mutations Predict Prognosis in Bulgarian Glioblastoma Patients

Abstract

Mutations in genes encoding isocitrate dehydrogenase isoforms 1 (IDH1) and 2 (IDH2) have been associated with good prognosis for patients with brain neoplasias and have been commonly found together with mutatedTP53gene. To determine the prevalence ofIDH1,IDH2, andTP53mutations and their impact on overall survival 106 glioblastoma patients were analysed.IDH1mutations were detected in 13 andIDH2mutation in one patient. Two homozygous samples with R132H mutation inIDH1gene and a novel aberration K129R inIDH2gene were found. Sixty-four percent ofIDH1/IDH2mutated tumours harboured also a mutation inTP53gene. Genetic aberrations inTP53were present in 37 patients. Statistical analysis of the impact of the studied factors on the overall survival showed that the mutations inIDH1/IDH2, but not the ones inTP53, were associated with longer survival. Also, the impact of age on prognosis was confirmed. This is the first comprehensive study on glioblastomas in Bulgaria. Our results suggest thatIDH1/IDH2but notTP53mutations together with other prognostic factors such as age might be applied in clinical practice for prediction of outcome in patients with glioblastomas.