Parasitaemia and Its Relation to Hematological Parameters and Liver Function among Patients Malaria in Abs, Hajjah, Northwest Yemen

Abstract

Plasmodium falciparummalaria is the most common infection in Yemen. The present study aims to investigate changes in hematological and hepatic function indices ofP. falciparuminfected individuals. This study included 67 suspectedfalciparummalarial patients attended in clinics and rural Abs Hospital (Tehama, Hajjah), Yemen, from October 2013 to April 2014. The diagnosis of malaria was confirmed by thick and thin film with Giemsa staining of malaria parasite. Hematological parameters and serum levels of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and bilirubin (total and direct) as test indicators of liver function were studied. Patients with parasitaemia tended to have significantly lower hemoglobin, hematocrit, white blood cell count, lymphocytes, and platelets, compared with healthy normal subjects. Neutrophils levels were significantly higher in cases offalciparummalaria in comparison to healthy normal subjects. Serums AST, ALT, ALP, and bilirubin (total and direct) infalciparummalaria patients were significantly higher (p<0.0001) than those offalciparummalaria of free individuals. Hematological and liver dysfunctions measured parameters were seen associated with moderate and severe parasitaemia infection. This study concludes that hematological and hepatic dysfunction parameters could be indicator of malaria in endemic regions.