Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model

Author:

Seong Myeongsu1ORCID,Myoung NoSoung2,Lee Songhyun1ORCID,Jeong Hyeryun1,Yim Sang-Youp2ORCID,Kim Jae Gwan13ORCID

Affiliation:

1. Department of Biomedical Science and Engineering, Institute of Integrated Technology, Gwangju Institute of Science and Technology, 123 Cheomdan Gwagiro, Bukgu, Gwangju 61005, Republic of Korea

2. Advanced Photonics Research Institute, Gwangju Institute of Science and Technology, 123 Cheomdan Gwagiro, Bukgu, Gwangju 61005, Republic of Korea

3. School of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology, 123 Cheomdan Gwagiro, Bukgu, Gwangju 61005, Republic of Korea

Abstract

The cancer field effect (CFE) has been highlighted as one of indirect indications for tissue variations that are insensitive to conventional diagnostic techniques. In this research, we had a hypothesis that chemotherapy for breast cancer would affect skin biochemical compositions that would be reflected by Raman spectral changes. We used a fiber-optic probe-based Raman spectroscopy to perform preliminary animal experiments to validate the hypothesis. Firstly, we verified the probing depth of the fiber-optic probe (~800 μm) using a simple intravenous fat emulsion-filled phantom having a silicon wafer at the bottom inside a cuvette. Then, we obtained Raman spectra during breast cancer treatment by chemotherapy from a small animal model in longitudinal manner. Our results showed that the treatment causes variations of biochemical compositions in the skin. For further validation, the Raman spectra will have to be collected from more populations and spectra will need to be compared with immunohistochemistry of the breast tissue.

Funder

Ministry of Education, Science and Technology

Publisher

Hindawi Limited

Subject

Spectroscopy,Atomic and Molecular Physics, and Optics,Analytical Chemistry

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