No Association ofBDNF,COMT,MAOA,SLC6A3, andSLC6A4Genes and Depressive Symptoms in a Sample of Healthy Colombian Subjects

Abstract

Background. Major depressive disorder (MDD) is the second cause of years lived with disability around the world. A large number of studies have been carried out to identify genetic risk factors for MDD and related endophenotypes, mainly in populations of European and Asian descent, with conflicting results. The main aim of the current study was to analyze the possible association of five candidate genes and depressive symptoms in a Colombian sample of healthy subjects.Methods and Materials. The Spanish adaptation of the Hospital Anxiety and Depression Scale (HADS) was applied to one hundred eighty-eight healthy Colombian subjects. Five functional polymorphisms were genotyped using PCR-based assays:BDNF-Val66Met (rs6265),COMT-Val158Met (rs4680),SLC6A4-HTTLPR (rs4795541),MAOA-uVNTR, andSLC6A3-VNTR (rs28363170).Result. We did not find significant associations with scores of depressive symptoms, derived from the HADS, for any of the five candidate genes (nominalpvalues >0.05). In addition, we did not find evidence of significant gene-gene interactions.Conclusion. This work is one of the first studies of candidate genes for depressive symptoms in a Latin American sample. Study of additional genetic and epigenetic variants, taking into account other pathophysiological theories, will help to identify novel candidates for MDD in populations around the world.