Nanobiosensors Based on Localized Surface Plasmon Resonance for Biomarker Detection

Author:

Hong Yoochan1,Huh Yong-Min234,Yoon Dae Sung1,Yang Jaemoon245

Affiliation:

1. Department of Biomedical Engineering, Yonsei University, Wonju, Gangwondo 220-710, Republic of Korea

2. Department of Radiology, College of Medicine, Yonsei University, Seoul 120-749, Republic of Korea

3. Severance Biomedical Science Institute (SBSI), Seoul 120-752, Republic of Korea

4. YUMS-KRIBB Medical Convergence Center, College of Medicine, Yonsei University, Seoul 120-749, Republic of Korea

5. Severance Integrative Research Institute for Cerebral & Cardiovascular Diseases, Yonsei University Health System, Seoul 120-752, Republic of Korea

Abstract

Localized surface plasmon resonance (LSPR) is induced by incident light when it interacts with noble metal nanoparticles that have smaller sizes than the wavelength of the incident light. Recently, LSPR-based nanobiosensors were developed as tools for highly sensitive, label-free, and flexible sensing techniques for the detection of biomolecular interactions. In this paper, we describe the basic principles of LSPR-based nanobiosensing techniques and LSPR sensor system for biomolecule sensing. We also discuss the challenges using LSPR nanobiosensors for detection of biomolecules as a biomarker.

Funder

National Research Foundation of Korea

Publisher

Hindawi Limited

Subject

General Materials Science

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