Affiliation:
1. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
2. Cardiovascular Research Institute of Wuhan University, Wuhan 430060, China
3. Hubei Key Laboratory of Cardiology, Wuhan 430060, China
Abstract
Peroxisome proliferator-activated receptor-γ(PPARγ) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily, which plays a central role in regulating lipid and glucose metabolism. However, accumulating evidence demonstrates that PPARγagonists have potential to reduce inflammation, influence the balance of immune cells, suppress oxidative stress, and improve endothelial function, which are all involved in the cellular and molecular mechanisms of cardiac fibrosis. Thus, in this review we discuss the role of PPARγin various cardiovascular conditions associated with cardiac fibrosis, including diabetes mellitus, hypertension, myocardial infarction, heart failure, ischemia/reperfusion injury, atrial fibrillation, and several other cardiovascular disease (CVD) conditions, and summarize the developmental status of PPARγagonists for the clinical management of CVD.
Funder
National Natural Science Foundation of China
Subject
Pharmacology (medical),Drug Discovery
Cited by
34 articles.
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