Leiomyosarcoma of the Prostate: Case Report and Review of 54 Previously Published Cases

Author:

Vandoros Gerasimos P.1,Manolidis Theodoros1,Karamouzis Michalis V.23,Gkermpesi Maria1,Lambropoulou Maria4,Papatsoris Athanasios G.2,Zachos Ioannis1,Konstantinopoulos Panagiotis A.25

Affiliation:

1. Department of Pathology, Aeghion General Hospital, 25100 Aeghion, Greece

2. Department of Biological Chemistry, Medical School, University of Athens, 115 27 Athens, Greece

3. Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, PA 15232, USA

4. Department of Histology/Embryology, Democritus University of Thrace, 68 100 Alexandroupolis, Greece

5. Division of Hematology and Oncology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA

Abstract

Prostate leiomyosarcoma is an extremely rare and highly aggressive neoplasm that accounts for less than 0.1% of primary prostate malignancies. We present a patient with primary leiomyosarcoma of the prostate and review 54 cases reported in the literature to discuss the clinical, diagnostic and therapeutic aspects of this uncommon tumor. Median survival was estimated at 17 months (95% C.I. 20.7–43.7 months) and the 1-, 3-, and 5-year actuarial survival rates were 68%, 34%, and 26%, respectively. The only factors predictive of long-term survival were negative surgical margins and absence of metastatic disease at presentation. A multidisciplinary approach is necessary for appropriate management of this dire entity.

Publisher

Hindawi Limited

Subject

Radiology Nuclear Medicine and imaging,Oncology

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