Preparation of Gelatin/Polycaprolactone Electrospun Fibers Loaded with Cis-Platinum and Their Potential Application for the Treatment of Prostate Cancer

Abstract

Although the development of nanomaterials for cancer therapy has received much attention in recent years, prostate cancer still remains one of the most troubling cancers in males. In this work, biomimetic polycaprolactone (PCL)/gelatin (GT)/cis-platinum (CDDP) (PG@CDDP) fibrous films were developed via electrospinning technology. The microstructure and chemical properties of PG@CDDP fibers are investigated. It is found that the microscopic morphology and diameter of PG@CDDP fibers are changed compared to those of the PG fibers. The Fourier transform-infrared spectroscopy and wide-angle X-ray diffraction demonstrate that CDDP is successfully incorporated into the fibers. The human prostate cancer cells in vitro to electrospun films (PG and PG@CDDP) were evaluated based on initial cell response and cell viability. The density, elongation, and viability of adhered cancer cells significantly reduce with an increased concentration of CDDP in PG fibers. Thus, the developed PG@CDDP fiber matrix has great potential as candidate scaffolds for the treatment of prostate cancer.