The Effect of Granulocyte Colony-Stimulating Factor on the Progression of Atherosclerosis in Animal Models: A Meta-Analysis

Author:

Liu Manli12,Liu Kejian34,Chen Dongdong12,Chen Hongzhi12,Sun Kunming12,Ju Xinxin12,Lan Jiaojiao12,Zhou Yang12,Wang Weishan5ORCID,Pang Lijuan12ORCID

Affiliation:

1. Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Ministry of Education, Shihezi University School of Medicine, Shihezi, Xinjiang, China

2. Department of Pathology, The First Affiliated Hospital to Shihezi University School of Medicine, Shihezi, Xinjiang, China

3. Department of Cardiology, The First Affiliated Hospital to Shihezi University School of Medicine, 45 North 3rd Road, Shihezi, Xinjiang, China

4. Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, China

5. Department of Orthopaedics, Shihezi University School of Medicine, 45 North 3rd Road, Shihezi, Xinjiang, China

Abstract

Background. Atherosclerosis is a common inflammatory disease. Stem cell and endothelial progenitor cell treatments can improve cardiac function after myocardial infarction. Granulocyte colony-stimulating factor (G-CSF) is a mobilisation agent, mobilising stem cells from the bone marrow to circulation in the blood. G-CSF may constitute a treatment of atherosclerosis. We have conducted meta-analysis to evaluate the current evidence for the effect of G-CSF on the progression of atherosclerosis in animal models and to provide reference for preclinical experiments and future human clinical trials of atherosclerosis treatment.Methods. We searched several databases and conducted a meta-analysis across seven articles using a random-effect model. All statistical analyses were performed using Review Manager Version 5.2 and Stata 12.0.Results. We found that G-CSF therapy was associated with reduced atherosclerotic lesion area (weighted mean difference (WMD): 7.29%; 95% confidence interval (CI): 2.06–12.52%;P=0.006). No significant differences in total serum cholesterol (P=0.54) and triglyceride levels (P=0.95) were noted in G-CSF treatment groups compared with controls. Multivariable metaregression analysis revealed that the animal type (rabbit,P=0.022) and frequency of G-CSF administration (>20,P=0.007) impacted the atherosclerotic lesion area changes.Conclusion. The meta-analysis suggested that G-CSF treatment might inhibit the progression of atherosclerosis in animal models.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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