Synthesis and Cytotoxicity of Silicon Containing Pyridine and Quinoline Sulfides-Reference-Cited by-同舟云学术

Synthesis and Cytotoxicity of Silicon Containing Pyridine and Quinoline Sulfides

Published:2002-01-01 Issue:1-2 Volume:9 Page:45-51
ISSN:0793-0291
Container-title:Metal-Based Drugs
language:en
Short-container-title:Metal-Based Drugs

Author:

Lukevics Edmunds¹,Abele Edgars¹,Arsenyan Pavel¹,Abele Ramona¹,Rubina Kira¹,Shestakova Irina¹,Domracheva Ilona¹,Vologdina Violetta¹

Affiliation:

1. Latvian Institute of Organic Synthesis, 21 Aizkraukles Street, Riga LV-I006, Latvia

Abstract

Silicon containing pyridine and quinoline sulfides have been prepared using phase transfer catalytic system thiol/alkyl halide / solid KOH/18-crown-6 / toluene. The target S-ethers were isolated in yields up to 81%. The cytotoxicity of the synthesized compounds was studied. Among pyridine sulfides S-[3-(1-methyl- 1-silacyclohexyl)propyl] derivatives 5e and 6e exhibit the highest cytotoxicity. Aliphatic silicon derivatives were considerably less active. 8-[(Trimethylsilylmethyl)thio]quinoline (8a) exhibits the highest activity among quinoline sulfides.

Publisher

Hindawi Limited

Subject

Inorganic Chemistry,Drug Discovery,Pharmacology,Toxicology

Link

http://downloads.hindawi.com/archive/2002/535396.pdf

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