An Outbreak of Coxsackievirus A6 Infection in Adults of a Collective Unit, China, 2019

Author:

Gao Yumeng1ORCID,Ma Guangyuan2ORCID,Xiao Yong2,Cai Qun3ORCID,Chen Yujun1ORCID,Shi Ping1ORCID,Wang Kewei4,Shen Yuan1ORCID,Shi Chao5ORCID

Affiliation:

1. Department of Acute Infectious Disease Prevention and Control, Wuxi Center for Disease Control and Prevention, Wuxi, Jiangsu, China

2. Microbiological Laboratory, Wuxi Center for Disease Control and Prevention, Wuxi, Jiangsu, China

3. Department of Acute Infectious Disease Prevention and Control, Hui Shan Center for Disease Control and Prevention, Hui Shan, Wuxi, Jiangsu, China

4. Department of Nosocomial Infection, Affiliated Hospital of Jiangnan University, Liangxi, Wuxi, Jiangsu, China

5. Department of Acute Infectious Disease Prevention and Control, Wuxi Center for Disease Control and Prevention, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi, Jiangsu, China

Abstract

Outbreaks/epidemics caused by coxsackievirus A6 (CVA6) have been reported continuously since 2008. However, outbreaks of ocular conjunctival hemorrhage caused by CVA6 in adults in a collective unit have not been reported. Methods. The epidemiological investigations were carried out according to the monitoring program, and the clinical data were collected from the treated hospitals. The nasopharyngeal swab specimens were collected to extract the total nucleic acid (DNA/RNA). The pathogen was determined using nucleic acid detection kits for 22 respiratory pathogens. The VP1 gene of this pathogen was amplified and sequenced. Sequence alignment and analysis were performed using BioEdit 7.0. The gene phylogenetic tree was constructed with MEGA4.0. Results. The factory emerged patients in succession from February 14 and reached the peak on the 18th. A total of 19 workers had symptoms in this factory up to March 31, 2019, giving an attack rate of 8.26%. The main symptoms were rash, ocular conjunctival hemorrhage, fever, and sore throat. The laboratory results showed that coxsackievirus A6 was the main pathogen causing this outbreak. The risk of taking a bath in the bathroom was 7.37 times higher than that of not taking a bath (95% confidence interval (CI): 1.67–32.79). Conclusion. This manuscript further enriched the infection-related information of CVA6, which was helpful to better identify and deal with the epidemic in the future.

Funder

Project of Public Health Research Center at Jiangnan University

Publisher

Hindawi Limited

Subject

Infectious Diseases,Microbiology (medical)

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