Analysis of Apparent Diffusion Coefficient Value and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameters of Prostate Cancer Patients after Diagnosis and Treatment with Magnetic Resonance Imaging

Abstract

This research was aimed at exploring the changes in the apparent diffusion coefficient (ADC) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters of prostate cancer (PCa) patients. Sixty PCa patients from the hospital were recruited as the research object, and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) scans were performed to determine the shape, scope, and enhancement characteristics of prostate lesions and their relationship with surrounding tissues. The quantitative parameters of ADC and DCE-MRI were measured. There were 4 patients (6.67%) with a Gleason score of 6 and 15 patients (25%) with a $4+3$ score. The ADC with $\text{Gleason}=6$ is $0.81\pm 0.08\times {10}^{-3}\text{s}/\text{m}{\text{m}}^2$ , the ADC with $\text{Gleason}=3+4$ is $0.74\pm 0.07\times {10}^{-3}\text{s}/\text{m}{\text{m}}^2$ , the ADC with $\text{Gleason}=4+3$ is $0.73\pm 0.05\times {10}^{-3}\text{s}/\text{m}{\text{m}}^2$ , the ADC with $\text{Gleason}=9$ is $0.65\pm 0.06\times {10}^{-3}\text{s}/\text{m}{\text{m}}^2$ , and the ADC with $\text{Gleason}=10$ is $0.59\pm 0.07\times {10}^{-3}\text{s}/\text{m}{\text{m}}^2$ . As the Gleason score increased, the ADC decreased and the permeation parameter transfer constant increased. When the ADC was combined with the permeability parameter transfer constant, the AUC of $\text{Gleason}=6$ points and $\text{Gleason}=7$ points was greatly different ( $P<0.05$ ). The 95% CI of the ADC combined permeability parameter transport constant when $\text{Gleason}=6$ points and $\text{Gleason}=7$ points was 0.898-0.934, the sensitivity was 75.4%, and the specificity was 86.2%. The ADC value was negatively correlated with Gleason score. The ADC value combined with VTC value has good diagnostic performance in evaluating the invasion of PCa, which is very important for making treatment plan and evaluating prognosis.