Paving Plant-Food-Derived Bioactives as Effective Therapeutic Agents in Autism Spectrum Disorder-Reference-Cited by-同舟云学术

Paving Plant-Food-Derived Bioactives as Effective Therapeutic Agents in Autism Spectrum Disorder

Published:2021-08-21 Issue: Volume:2021 Page:1-17
ISSN:1942-0994
Container-title:Oxidative Medicine and Cellular Longevity
language:en
Short-container-title:Oxidative Medicine and Cellular Longevity

Author:

Cruz-Martins Natália¹²³^ORCID,Quispe Cristina⁴,Kırkın Celale⁵,Şenol Ezgi⁶,Zuluğ Aslı⁷,Özçelik Beraat⁸⁹^ORCID,Ademiluyi Adedayo O.¹⁰,Oyeniran Olubukola Helen¹⁰,Semwal Prabhakar¹¹¹²^ORCID,Kumar Manoj¹³^ORCID,Sharopov Farukh¹⁴,López Victor¹⁵¹⁶,Les Francisco¹⁵¹⁶^ORCID,Bagiu Iulia-Cristina¹⁷¹⁸^ORCID,Butnariu Monica¹⁹^ORCID,Sharifi-Rad Javad²⁰^ORCID,Alshehri Mohammed M.²¹^ORCID,Cho William C.²²^ORCID

Affiliation:

1. Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

2. Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal

3. Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU), Rua Central de Gandra, 1317, 4585-116, Gandra, PRD, Portugal

4. Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique 1110939, Chile

5. Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, 34469 Istanbul, Turkey

6. Department Food Engineering, Faculty of Engineering and Natural Sciences, Istanbul Sabahattin Zaim University, Beyoglu, 34427 Istanbul, Turkey

7. Department of Gastronomy and Culinary Arts, School of Applied Sciences, Ozyegin University, Cekmekoy, 34794 Istanbul, Turkey

8. Department Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, 34469 Istanbul, Turkey

9. BIOACTIVE Research & Innovation Food Manufacturing Industry Trade Ltd. Co., Maslak, Istanbul 34469, Turkey

10. Functional Foods, Nutraceuticals, and Phytomedicine Unit, Department of Biochemistry, Federal University of Technology, Akure 340001, Nigeria

11. Department of Biotechnology, Graphic Era University, Dehradun, Uttarakhand, India

12. Uttarakhand State Council for Science and Technology, Dehradun, Uttarakhand, India

13. Chemical and Biochemical Processing Division, ICAR - Central Institute for Research on Cotton Technology, Mumbai 400019, India

14. Department of Pharmaceutical Technology, Avicenna Tajik State Medical University, Rudaki 139, 734003 Dushanbe, Tajikistan

15. Facultad de Ciencias de la Salud, Universidad San Jorge, Villanueva de Gállego, Zaragoza, Spain

16. Instituto Agroalimentario de Aragón (IA2), Universidad de Zaragoza-CITA, Zaragoza, Spain

17. Victor Babes University of Medicine and Pharmacy of Timisoara, Department of Microbiology, Timisoara, Romania

18. Multidisciplinary Research Center on Antimicrobial Resistance, Timisoara, Romania

19. Banat’s University of Agricultural Sciences and Veterinary Medicine “King Michael I of Romania” from Timisoara, Timisoara, Romania

20. Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

21. Pharmaceutical Care Department, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia

22. Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder, where social and communication deficits and repetitive behaviors are present. Plant-derived bioactives have shown promising results in the treatment of autism. In this sense, this review is aimed at providing a careful view on the use of plant-derived bioactive molecules for the treatment of autism. Among the plethora of bioactives, curcumin, luteolin, and resveratrol have revealed excellent neuroprotective effects and can be effectively used in the treatment of neuropsychological disorders. However, the number of clinical trials is limited, and none of them have been approved for the treatment of autism or autism-related disorder. Further clinical studies are needed to effectively assess the real potential of such bioactive molecules.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Hindawi Limited

Subject

Cell Biology,Ageing,General Medicine,Biochemistry

Link

http://downloads.hindawi.com/journals/omcl/2021/1131280.pdf

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