Serum Dickkopf-1 Level in Postmenopausal Females: Correlation with Bone Mineral Density and Serum Biochemical Markers

Abstract

Objective. To assess serum level of Dickkopf-1 in postmenopausal females and its correlation with bone mineral density and serum biochemical markers.Methods. Bone densitometry, serum Dickkopf-1, calcium, phosphorus, and alkaline phosphatase were done in sixty postmenopausal females. Patients were divided according toTscore into osteoporosis (group I), osteopenia (group II), and normal bone mineral density that served as controls.Results. There was highly significant increase in serum Dickkopf-1 levels in postmenopausal females with abnormalTscore versus controls (P<0.001). Serum DKK-1 levels correlated negatively with both lumbarTscore (r=-0.69,P<0.001) and femurTscore (r=-0.64,P<0.001) and correlated positively with duration of menopause (r=0.61,P<0.001), while there was no significant correlation between serum levels of either calcium, phosphorus or alkaline phosphatase, and both serum Dickkopf-1 levels and the level of bone mineral density (P>0.05).Conclusion. Postmenopausal females may suffer from osteoporosis as evidenced by bone densitometry. Postmenopausal women with significantly increased serum Dickkopf-1 had more significant osteoporosis. Prolonged duration of menopause and increased serum Dickkopf-1 are important risk factors for the development and severity of osteoporosis.