Urtica dioica-Derived Phytochemicals for Pharmacological and Therapeutic Applications

Author:

Taheri Yasaman1ORCID,Quispe Cristina2,Herrera-Bravo Jesús34ORCID,Sharifi-Rad Javad15ORCID,Ezzat Shahira M.67ORCID,Merghany Rana M.8,Shaheen Shabnum9,Azmi Lubna10,Prakash Mishra Abhay11ORCID,Sener Bilge12,Kılıç Mehtap13,Sen Surjit1415,Acharya Krishnendu14,Nasiri Azadeh16,Cruz-Martins Natália17181920ORCID,Tsouh Fokou Patrick Valere21ORCID,Ydyrys Alibek22,Bassygarayev Zhandos23,Daştan Sevgi Durna2425,Alshehri Mohammed M.26ORCID,Calina Daniela27ORCID,Cho William C.28ORCID

Affiliation:

1. Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2. Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique 1110939, Chile

3. Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomas, Chile

4. Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de La Frontera, Temuco, 4811230, Chile

5. Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador

6. Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El Ainy Street, Cairo 11562, Egypt

7. Department of Pharmacognosy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 6th of October 12451, Egypt

8. Department of Pharmacognosy, National Research Centre, Giza, Egypt

9. Department of Plant Sciences, LCWU, Lahore 54000, Pakistan

10. Hygia Institute of Pharmaceutical Education & Research, Lucknow, U. P. 226001, India

11. Department of Pharmacology, University of Free State, Bloemfontein 9300, Free State, South Africa

12. Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, Ankara 06330, Turkey

13. Department of Pharmacognosy, Lokman Hekim University Faculty of Pharmacy, Ankara 06510, Turkey

14. Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata 700019, India

15. Department of Botany, Fakir Chand College, Diamond Harbour, West Bengal 743331, India

16. Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

17. Faculty of Medicine, University of Porto, Porto, Portugal

18. Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal

19. Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU), Rua Central de Gandra, 1317, Gandra PRD 4585-116, Portugal

20. TOXRUN-oxicology Research Unit, University Institute of Health Sciences, CESPU, CRL, Gandra 4585-116, Portugal

21. Department of Biochemistry, Faculty of Science, University of Bamenda, Bambili, P.O. Box. 39, Cameroon

22. Biomedical Research Centre, Al-Farabi Kazakh National University, Al-Farabi av. 71, Almaty 050040, Kazakhstan

23. Department of Biophysics, Biomedicine and Neuroscience, Al-Farabi Kazakh National University, Al-Farabi av. 71, Almaty 050040, Kazakhstan

24. Department of Biology, Faculty of Science, Sivas Cumhuriyet University, Sivas 58140, Turkey

25. Beekeeping Development Application and Research Center, Sivas Cumhuriyet University, Sivas 58140, Turkey

26. Pharmaceutical Care Department, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia

27. Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova 200349, Romania

28. Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong

Abstract

Urtica dioica belongs to the Urticaceae family and is found in many countries around the world. This plant contains a broad range of phytochemicals, such as phenolic compounds, sterols, fatty acids, alkaloids, terpenoids, flavonoids, and lignans, that have been widely reported for their excellent pharmacological activities, including antiviral, antimicrobial, antihelmintic, anticancer, nephroprotective, hepatoprotective, cardioprotective, antiarthritis, antidiabetic, antiendometriosis, antioxidant, anti-inflammatory, and antiaging effects. In this regard, this review highlights fresh insight into the medicinal use, chemical composition, pharmacological properties, and safety profile of U. dioica to guide future works to thoroughly estimate their clinical value.

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

Reference142 articles.

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