Prevalence of Anemia in Pediatric IBD Patients and Impact on Disease Severity: Results of the Pediatric IBD-Registry CEDATA-GPGE®

Author:

Laffolie Jan de1ORCID,Laass Martin W.2,Scholz Dietmar3,Zimmer Klaus-Peter1,Buderus Stephan4,CEDATA-GPGE Study Group 5

Affiliation:

1. General Pediatrics & Neonatology, Justus-Liebig-University, Giessen, Germany

2. Department of Pediatrics, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

3. Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University of Leipzig, Leipzig, Germany

4. Pediatric and Adolescent Medicine, GFO Kliniken Bonn, St. Marien-Hospital, Bonn, Germany

5. Gesellschaft für pädiatrische Gastroenterologie und Ernährung, Chausseestr 128-129, Berlin, Germany

Abstract

Aim. To determine the prevalence of anemia and its association with disease severity in children and adolescents with IBD. Methods. CEDATA-GPGE is a registry for pediatric patients with IBD in Germany and Austria from 90 specialized centers. As markers of disease severity, analysis included patient self-assessment on a Likert scale (1–5; 1 = very good) and physicians’ general assessment (0 = no activity to 4 = severe disease) and the disease indices. Anemia was defined as hemoglobin concentration below the 3rd percentile. Results. Prevalence of anemia was 65.2% in CD and 60.2% in UC. Anemic CD and UC patients showed significantly worse self-assessment than patients without anemia (average ± standard deviation; CD: 3.0 ± 0.9 versus 2.5 ± 0.9, p<0.0001; UC: 2.9 ± 0.9 versus 2.3 ± 0.9, p<0.0001). Accordingly, physicians’ general assessment (PGA) was significantly worse in anemic than in nonanemic patients in CD (p<0.0001) and UC (p<0.0001). PCDAI in anemic CD, p<0.0001, and PUCAI in anemic UC patients, p<0.0001, were significantly higher than in nonanemic patients. 40.0% of anemic CD and 47.8% of anemic UC patients received iron during follow-up. Conclusion. Almost 2/3 of pediatric IBD patients are anemic. Patients’ self-assessment and disease severity as determined by PGA and activity indices are worse in anemic patients. Contrastingly, only a minority received iron therapy.

Funder

German Crohn’s and Colitis Association

Publisher

Hindawi Limited

Subject

Gastroenterology,Hepatology

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